*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UX9363950
CHEMICAL NAME           : 1H-Pyrrole-1-carboxamide,
                          2,5-dihydro-3-ethyl-4-methyl-N-(2-(4-(((((4-methylcyc
                          lohexyl)amino)
                          carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo-, trans-
CAS REGISTRY NUMBER     : 93479-97-1
BEILSTEIN REFERENCE NO. : 5365754
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C24-H34-N4-O5-S
MOLECULAR WEIGHT        : 490.68
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Glimepirid
   * Glimepiride
   * HOE 490
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 43,547,1993
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3950 mg/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 43,547,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DIFREZ Diabetes Frontier.  (Medikaru Rebyusha, Yoshida Bldg., 1-7-3
   Hirano-machi, Chuo-ku, Osaka, 541, Japan)  V.1-    1990-
   Volume(issue)/page/year: 3,565,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DIFREZ Diabetes Frontier.  (Medikaru Rebyusha, Yoshida Bldg., 1-7-3
   Hirano-machi, Chuo-ku, Osaka, 541, Japan)  V.1-    1990-
   Volume(issue)/page/year: 3,565,1992
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 254 ug/kg
SEX/DURATION            : female 7-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - abortion
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 27,1477,1993
 
                            *** END OF RECORD ***