*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UX1750000
CHEMICAL NAME           : Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di-
CAS REGISTRY NUMBER     : 500-38-9
LAST UPDATED            : 199806
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C18-H22-O4
MOLECULAR WEIGHT        : 302.40
WISWESSER LINE NOTATION : QR BQ D1Y1&Y1&1R CQ DQ
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * 2,3-Bis(3,4-dihydroxyphenylmethyl)butane
   * Butane, 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl-
   * Dihydronorguaiaretic acid
   * beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane
   * 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol
   * Dinorguaiaretic acid, dihydro-
   * NDGA
   * Nordihydroguaiaretic acid
   * Nordihydroguairaretic acid
   * Norguaiaretic acid, dihydro-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAOCA7 Journal of the American Oil Chemists' Society.  (Champaign, IL)
   V.24-56, 1947-79.  Volume(issue)/page/year: 54,239,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAOCA7 Journal of the American Oil Chemists' Society.  (Champaign, IL)
   V.24-56, 1947-79.  Volume(issue)/page/year: 54,239,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 550 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AFREAW Advances in Food Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-32, 1948-88.  Volume(issue)/page/year: 3,197,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 830 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AFREAW Advances in Food Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-32, 1948-88.  Volume(issue)/page/year: 3,197,1951
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 13500 nmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 412,139,1998
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 3600 nmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 412,139,1998
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 70700 ug/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 412,139,1998
 
TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 35300 ug/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 412,139,1998
 
                            *** END OF RECORD ***