*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UW7875000
CHEMICAL NAME           : Pyrimido(5,4-e)-as-triazine-5,7-(1H,6H)-dione,
                          1,6-dimethyl-
CAS REGISTRY NUMBER     : 84-82-2
BEILSTEIN REFERENCE NO. : 0021014
REFERENCE               : 4-26-00-04141 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C7-H7-N5-O2
MOLECULAR WEIGHT        : 193.19
WISWESSER LINE NOTATION : T66 BVNVN GNN JNJ C1 G1
SYNONYMS/TRADE NAMES :
   *   1,6-Dimethyl-5,7-dioxo-1,5,6,7-tetrahydropyrimido(5,4-E)-as-triazine-5,7
     (1H,6H)-dione
   * 1,6-Dimethylpyrimido(5,4-e)-as-triazine-5,7(1H,6H)-dione
   * Pyrimido(5,4-e)-1,2,4-triazine-5,7-(1H,6H)-dione, 1,6-dimethyl-
   * Toxoflavin
   * Toxoflavine
   * Xanthothricin
   * Xanthotricin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8400 ug/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - hematuria
   Gastrointestinal - hypermotility, diarrhea
   Sense Organs and Special Senses (Eye) - lacrimation
REFERENCE :
   ANTCAO Antibiotics and Chemotherapy (Washington, DC).  (Washington, DC)
   V.1-12, 1951-62.  For publisher information, see CLMEA3.
   Volume(issue)/page/year: 4,259,1954
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOCEAH Journal of Organic Chemistry.  (American Chemical Soc., Distribution
   Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037)  V.1-
   1936-  Volume(issue)/page/year: 31,900,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1700 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Gastrointestinal - hypermotility, diarrhea
   Kidney, Ureter, Bladder - hematuria
REFERENCE :
   ANTCAO Antibiotics and Chemotherapy (Washington, DC).  (Washington, DC)
   V.1-12, 1951-62.  For publisher information, see CLMEA3.
   Volume(issue)/page/year: 4,259,1954
 
                            *** END OF RECORD ***