*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UW7681600
CHEMICAL NAME           : 6H-Pyrimido(4,5-b)(1,4)benzothiazine,
                          7,8-dihydro-9-amino-7,7-dimethyl-4-(methylamino)-,
                          hydrobromide
CAS REGISTRY NUMBER     : 80761-76-8
LAST UPDATED            : 198612
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C13-H17-N5-S.Br-H
MOLECULAR WEIGHT        : 356.33
WISWESSER LINE NOTATION : T C666 BS DN FN IN NU&&TJ GM1 L1 L1 NZ &EH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   7,8-Dihydro-9-amino-7,7-dimethyl-4-(methylamino)-6H-pyrimido(4,5-b)(1,4)
     benzothiazine HBr
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle contraction or spasticity
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 15,785,1981
 
                            *** END OF RECORD ***