*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UW7373310
CHEMICAL NAME           : 4(1H)-Pyrimidinone,
                          2-((4-(5-bromo-3-methyl-2-pyridinyl)butyl)amino)-5-((
                          6-methyl-3-pyridinyl) methyl)-
CAS REGISTRY NUMBER     : 86181-44-4
LAST UPDATED            : 199606
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H24-Br-N5-O
MOLECULAR WEIGHT        : 442.41
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * SKF 93944
   * Temelastine
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 109 mg/kg/1Y-I
TOXIC EFFECTS :
   Endocrine - other changes
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   14,71,1990
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 54600 mg/kg/26W-I
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - dehydrogenases
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   14,71,1990
 
                            *** END OF RECORD ***