*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UW0492000
CHEMICAL NAME           : 2,4,5,6(1H,3H)-Pyrimidinetetrone, monohydrate
CAS REGISTRY NUMBER     : 2244-11-3
LAST UPDATED            : 199603
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C4-H2-N2-O4.H2-O
MOLECULAR WEIGHT        : 160.10
WISWESSER LINE NOTATION : T6MVMVVVJ &QH
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Mesoxalylcarbamide monohydrate
   * Mesoxalylurea monohydrate
   * 2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate
   * 2,4,5,6-Tetraoxohexahydropyrimidine hydrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DIAEAZ Diabetes.  (American Diabetes Assoc., 2 Park Ave., New York, NY
   10016)  V.1-    1952-  Volume(issue)/page/year: 12,66,1963
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - pig
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Endocrine - diabetes mellitus
   Endocrine - hyperglycemia
REFERENCE :
   METAAJ Metabolism, Clinical and Experimental.  (Grune & Stratton, Inc.,
   Journal Subscriptions Dept., POB 6280, Duluth, MN 55806)  V.1-    1952-
   Volume(issue)/page/year: 29,40,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 65400 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 87,382,1946
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 60 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   JEEMAF Journal of Embryology and Experimental Morphology.  (Essex, UK)
   V.1-98, 1953-86. For Publisher information, see DEVPED
   Volume(issue)/page/year: 41,93,1977
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 1 pph
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,325,1985
 
                            *** END OF RECORD ***