*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UV9290000
CHEMICAL NAME           : Pyrimidine,
                          4-methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-me
                          thyl-
CAS REGISTRY NUMBER     : 18694-40-1
BEILSTEIN REFERENCE NO. : 0751084
REFERENCE               : 5-25-18-00012 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C11-H14-N4-O2
MOLECULAR WEIGHT        : 234.29
WISWESSER LINE NOTATION : T6N CNJ B- AT5NNJ C1 EO1& DO1 F1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * DA-398
   * Epirizole
   * Mebron
   * Mepirizol
   * Mepirizole
   * 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin
   * 4-Methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methylpyrimidine
   * 2-(3-Methoxy-5-methylpyrazol-2-yl)-4-methoxy-6-methylpyrimidine
   * 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole
   * 2-(3-Methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methylpyrimidine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 445 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMGZAI Japan Medical Gazette.  (Tokyo, Japan)  V.1-18(?), 1964-81.
   Discontinued.  Volume(issue)/page/year: 7(9),5,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 214 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMGZAI Japan Medical Gazette.  (Tokyo, Japan)  V.1-18(?), 1964-81.
   Discontinued.  Volume(issue)/page/year: 7(9),5,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 208 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 8,494,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 214 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85IRAK "Modern Pharmaceuticals of Japan, V," Tokyo, Japan Pharmaceutical,
   Medical and Dental Supply Exporters' Assoc.,  1975 Volume(issue)/page/year:
   -,87,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 740 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 16,1011,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 540 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 16,1011,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 550 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 8,494,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 550 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMGZAI Japan Medical Gazette.  (Tokyo, Japan)  V.1-18(?), 1964-81.
   Discontinued.  Volume(issue)/page/year: 7(9),5,1970
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 45500 mg/kg/26W-C
TOXIC EFFECTS :
   Gastrointestinal - changes in structure or function of salivary glands
   Liver - changes in liver weight
   Endocrine - changes in adrenal weight
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 8,524,1977
 
                            *** END OF RECORD ***