*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UV8195000
CHEMICAL NAME           : Pyrimidine, 2,4-diamino-6-ethyl-5-phenyl-
CAS REGISTRY NUMBER     : 27653-49-2
BEILSTEIN REFERENCE NO. : 0190097
REFERENCE               : 5-25-12-00255 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C12-H14-N4
MOLECULAR WEIGHT        : 214.30
WISWESSER LINE NOTATION : T6N CNJ BZ DZ ER& F2
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 2,4-Diamino-6-ethyl-5-phenylpyrimidine
   * 2,4-Diamino-5-phenyl-6-ethylpyrimidine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 126 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AAGEAA Arkhiv Anatomii, Gistologii i Embriologii.  Archives of Anatomy,
   Histology and Embryology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-101, 1916-91.  Discontinued  Volume(issue)/page/year: 71(7),29,1976
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - cytological changes (including
   somatic cell genetic material)
REFERENCE :
   SJDBA9 Soviet Journal Developmental Biology (English Translation).
   Translation of Ontogenez. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.1-    1970-  Volume(issue)/page/year: 7,45,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   AAGEAA Arkhiv Anatomii, Gistologii i Embriologii.  Archives of Anatomy,
   Histology and Embryology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-101, 1916-91.  Discontinued  Volume(issue)/page/year: 71(7),29,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   AAGEAA Arkhiv Anatomii, Gistologii i Embriologii.  Archives of Anatomy,
   Histology and Embryology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-101, 1916-91.  Discontinued  Volume(issue)/page/year: 71(7),29,1976
 
                            *** END OF RECORD ***