*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UV7069500
CHEMICAL NAME           : Pyrimidine, 4,6-bis(1-aziridinyl)-5-chloro-2-methoxy-
CAS REGISTRY NUMBER     : 13150-25-9
BEILSTEIN REFERENCE NO. : 0805251
REFERENCE               : 5-25-12-00466 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C9-H11-Cl-N4-O
MOLECULAR WEIGHT        : 226.69
WISWESSER LINE NOTATION : T6N CNJ BO1 D- AT3NTJ& EG F- AT3NTJ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4,6-Bis(1-aziridinyl)-5-chloro-2-methoxypyrimidine
   * 4,6-Di(ethyleneimino)-2-methoxy-5-chloropyrimidine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 16 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   FATOBP Farmakologiya i Toksikologiya (Kiev).  Pharmacology and Toxicology.
   (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii,
   Kiev, USSR)  No.1-    1964-  Volume(issue)/page/year: 5,101,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   FATOBP Farmakologiya i Toksikologiya (Kiev).  Pharmacology and Toxicology.
   (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii,
   Kiev, USSR)  No.1-    1964-  Volume(issue)/page/year: 5,101,1970
 
                            *** END OF RECORD ***