*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UV1155900
CHEMICAL NAME           : Pyrido(2,3-d)pyrimidine,
                          2,4-diamino-6-sec-butyl-5-methyl-
CAS REGISTRY NUMBER     : 7319-47-3
BEILSTEIN REFERENCE NO. : 0614824
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C12-H17-N5
MOLECULAR WEIGHT        : 231.34
WISWESSER LINE NOTATION : T66 BN DN JNJ CZ EZ G1 HY2&1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * BW 58-283
   * BW 58-283b
   * BW 283U
   * 2,4-Diamino-5-methyl-6-sec-butylpyrido(2,3-d)pyrimidine
   * 2,4-Diamino-5-methyl-6-(but-2-yl)pyrido(2,3-d)pyrimidine
   * Pyrido(2,3-d)pyrimidine-2,4-diamine, 5-methyl-6-(1-methylpropyl)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   14XBAV "International Congress of Chemotherapy, Proceedings of the 3rd
   Congress, 1963," Kuemmerle, H.P., and Prezios, P., Stuttgart, Fed. Rep.
   Ger., Georg Thieme Verlag, 1964  Volume(issue)/page/year: -,367,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 57 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 11,711,1968
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 11 nmol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   25,1947,1976
 
                            *** END OF RECORD ***