*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UU8840000
CHEMICAL NAME           : 6H-Pyrido(4,3-b)carbazole, 5,11-dimethyl-9-methoxy-
CAS REGISTRY NUMBER     : 10371-86-5
BEILSTEIN REFERENCE NO. : 0279742
REFERENCE               : 5-23-12-00543 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C18-H16-N2-O
MOLECULAR WEIGHT        : 276.36
WISWESSER LINE NOTATION : T D6 B656 FN LMJ C1 J1 PO1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * AT 181
   * B 656501 K003
   * Ellipticine, 9-methoxy-
   * ICIG 772
   * 9-Methoxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazole
   * 9-Methoxyellipticin
   * Methoxyellipticine
   * 9-Methoxyellipticine
   * Methoxyelliptione
   * NSC 69187
   * 6H-Pyrido(4,3-b)carbazole, 9-methoxy-5,11-dimethyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BIMDB3 Biomedicine.  (Paris, France)  V.18-34, 1973-81.
   Volume(issue)/page/year: 21,101,1974
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 ng/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,3544,1983
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 100 ug/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,3544,1983

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation

 
                            *** END OF RECORD ***