*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UU8576000
CHEMICAL NAME           : 10H-Pyrido(3,2-b)(1,4)benzothiazine,
                          10-(3-(dimethylamino)propyl)-
CAS REGISTRY NUMBER     : 303-69-5
BEILSTEIN REFERENCE NO. : 0259865
REFERENCE               : 4-27-00-07169 (Beilstein Handbook Reference)
LAST UPDATED            : 199706
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C16-H19-N3-S
MOLECULAR WEIGHT        : 285.44
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Dimethylamino-n-propyl-thiophenylpyridylamine
   * Dominal
   * Largophren
   * LG 206
   * MH 05101
   * 10H-Pyrido(3,2-b)(1,4)benzothiazine-10-propanamine, N,N-dimethyl-
   * Prothipendyl
   * Timoval
   * Timovan
   * Tolnate
   * Tumovan
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 18,373,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 415 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 8,489,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   STRAAA Strahlentherapie.  (Urban & Schwarzenberg, Postfach 202440, D-8000
   Munich 2, Fed. Rep. Ger.) V.1-    1912-  Volume(issue)/page/year:
   127,245,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 102 mg/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 149,374,1964
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3040 mg/kg/22W-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 30,1709,1980

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   ADVPA3 Advances in Pharmacology.  (New York, NY)  V.1-6, 1962-68.  For
   publisher information, see AVPCAQ.  Volume(issue)/page/year: 4,263,1966

 
                            *** END OF RECORD ***