*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : UU7785940
CHEMICAL NAME : 4(1H)-Pyridinone, 1,2-dimethyl-3-hydroxy-
CAS REGISTRY NUMBER : 30652-11-0
BEILSTEIN REFERENCE NO. : 1447108
REFERENCE : 5-21-12-00114 (Beilstein Handbook Reference)
LAST UPDATED : 199803
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C7-H9-N-O2
MOLECULAR WEIGHT : 139.17
SYNONYMS/TRADE NAMES :
* CP20
* CP20 (Chelating agent)
* Deferiprone
* 1,2-Dimethyl-3-hydroxypyrid-4-one
* 1,2-Dimethyl-3-hydroxy-4(1H)-pyridinone
* L1
* 4(1H)-Pyridone, 3-hydroxy-1,2-dimethyl-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Cardiac - other changes
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
Volume(issue)/page/year: 18,202,1996
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
13,413,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 983 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BLOOAW Blood. (Grune & Stratton, Inc., 465 S. Lincoln Dr., Troy, MO 63379)
V.1- 1946- Volume(issue)/page/year: 76,2389,1990
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
BOMEEH BioMetals. (Rapid Communications of Oxford Ltd., The Old Malthouse,
Paradise St., Oxford OX1 1LD, UK) V.5- 1992 Volume(issue)/page/year:
10,247,1997
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
Volume(issue)/page/year: 18,202,1996
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4200 mg/kg/4W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
Endocrine - changes in spleen weight
Endocrine - changes in thymus weight
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos
540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year:
28(Suppl A),73,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 52 gm/kg/52W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos
540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year:
28(Suppl A),81,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8400 mg/kg/4W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
Endocrine - changes in spleen weight
Endocrine - changes in thymus weight
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos
540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year:
28(Suppl A),73,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 12 gm/kg/12W-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified)
Blood - changes in leukocyte (WBC) count
Related to Chronic Data - death
REFERENCE :
BLOOAW Blood. (Grune & Stratton, Inc., 465 S. Lincoln Dr., Troy, MO 63379)
V.1- 1946- Volume(issue)/page/year: 78,2727,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 3600 mg/kg/28D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - somnolence (general depressed activity)
Related to Chronic Data - death
REFERENCE :
BOMEEH BioMetals. (Rapid Communications of Oxford Ltd., The Old Malthouse,
Paradise St., Oxford OX1 1LD, UK) V.5- 1992 Volume(issue)/page/year:
10,247,1997
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 10500 mg/kg/35W-I
TOXIC EFFECTS :
Cardiac - cardiomyopathy including infarction
Liver - hepatitis (hepatocellular necrosis), diffuse
Blood - changes in leukocyte (WBC) count
REFERENCE :
BOMEEH BioMetals. (Rapid Communications of Oxford Ltd., The Old Malthouse,
Paradise St., Oxford OX1 1LD, UK) V.5- 1992 Volume(issue)/page/year:
10,247,1997
*** END OF RECORD ***