*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UU7700000
CHEMICAL NAME           : Pyridinium, 1,1'-trimethylenebis(4-formyl-,
                          dichloride, dioxime
CAS REGISTRY NUMBER     : 3613-82-9
LAST UPDATED            : 199106
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C15-H18-N4-O2.2Cl
MOLECULAR WEIGHT        : 357.27
WISWESSER LINE NOTATION : T6KJ D1UNQ A3- AT6KJ D1UNQ &G 2
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * 1,3-Bis(4-hydroxyiminomethyl-1-pyridinio)propane dichloride
   * 1,3-Bis(4-formylpyridinium)-propane bisoxime dichloride
   * Pyridinium, 1,1'-(1,3-propanediyl)bis((4-hydroxyimino)methyl)-,  
   dichloride
   * TMB-4 dichloride
   * Trimedoxime dichloride
   * 1,1'-Trimethylenebis(4-formylpyridinium chloride) dioxime
   * 1,1'-Trimethylenebis(4-formylpyridinium) dioxime dichloride
   * 1,1'-Trimethylenebis(4-(hydroxyiminomethyl)pyridinium chloride)
   * N,N-Trimethylene bis(pyridinium-4-aldoxime)dichloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   15,599,1967
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   15,599,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 88 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   16,194,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#00647
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 44 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 132,50,1961

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 53,1143,1964

 
                            *** END OF RECORD ***