*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UT8358900
CHEMICAL NAME           : Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl-
CAS REGISTRY NUMBER     : 28289-54-5
BEILSTEIN REFERENCE NO. : 0133712
REFERENCE               : 5-20-07-00121 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C12-H15-N
MOLECULAR WEIGHT        : 173.28
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
   * MPTP
   * 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 86 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   55HAAX "MPTP: A Neurotoxin Producing a Parkinsonian Syndrome, Papers
   Presented at a Symposium, Bethesda, MD, 1985," Markey, S.P., et al., eds.,
   Orlando, FL, Academic Press, Inc., 1986  Volume(issue)/page/year: -,571,1986
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg/3D-I
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - muscle weakness
   Behavioral - ataxia
REFERENCE :
   NETEEC Neurotoxicology and Teratology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.9-    1987- Volume(issue)/page/year:
   12,405,1990
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 252 mg/kg/7D-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Biochemical - Neurotransmitters or modulators (putative) - dopamine in
   striatum
REFERENCE :
   CHHTAT Zhonghua Yixue Zazhi.  Chinese Medical Journal.  (China International
   Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-    1915-   
   Suspended 1967-72.  Volume(issue)/page/year: 70,252,1990
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 2800 ug/kg/11D-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Biochemical - Neurotransmitters or modulators (putative) - dopamine at other
   sites
REFERENCE :
   CHHTAT Zhonghua Yixue Zazhi.  Chinese Medical Journal.  (China International
   Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-    1915-   
   Suspended 1967-72.  Volume(issue)/page/year: 70,252,1990
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : 8500 ug/kg/17D-I
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Behavioral - tremor
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JEPOEC Journal of Environmental Pathology, Toxicology and Oncology.
   (Chem-Orbital, POB 134, Park Forest, IL 60466)  V.5(4)-    1984-
   Volume(issue)/page/year: 9,417,1989
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 34 mg/kg
SEX/DURATION            : female 9-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   ANPTAL Acta Neuropathologica.  (Springer-Verlag New York, Inc., Service
   Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1961-
   Volume(issue)/page/year: 79,279,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 25200 ug/kg
SEX/DURATION            : female 9-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   ANPTAL Acta Neuropathologica.  (Springer-Verlag New York, Inc., Service
   Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1961-
   Volume(issue)/page/year: 79,279,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 50 mg/kg
SEX/DURATION            : female 1-20 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   EJPHAZ European Journal of Pharmacology.  (Elsevier Science Pub. B.V., POB
   211, 1000 AE Amsterdam, Netherlands)  V.1-    1967- Volume(issue)/page/year:
   217,211,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 375 mg/kg
SEX/DURATION            : female 10 day(s) pre-mating
                          female 20 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   EXNEAC Experimental Neurology.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year: 131,108,1995
 
                            *** END OF RECORD ***