*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UT1575000
CHEMICAL NAME           : Pyridine, 2-((2-(dimethylamino)ethyl)-3-thenylamino)-
CAS REGISTRY NUMBER     : 91-79-2
BEILSTEIN REFERENCE NO. : 0221267
REFERENCE               : 4-22-00-03953 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C14-H19-N3-S
MOLECULAR WEIGHT        : 261.42
WISWESSER LINE NOTATION : T6NJ BN2N1&1&1- CT5SJ
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * Diethylandiamine
   * N-(2-Dimethylaminoethyl)-N-2-pyridyl-3-thenylamine
   * 2-((2-Dimethylaminoethyl)-3-thenylamino)pyridine
   * 1,2-Ethanediamine, N,N-dimethyl-N'-2-pyridinyl-N'-(3-thienylmethyl)-
   * NCI-C60640
   * Tenfidil
   * Thefanil
   * Thenfadil
   * Thenyldiamine (pharmaceutical)
   * Thenyldiamine
   * WIN-2848
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Gastrointestinal - other changes
REFERENCE :
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 11,287,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 77 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 30 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981
 
                            *** END OF RECORD ***