*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UT7658000
CHEMICAL NAME           : Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-,
                          monohydrochloride, monohydrate, stereoisomer
CAS REGISTRY NUMBER     : 6138-79-0
LAST UPDATED            : 199803
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C19-H22-N2.Cl-H.H2-O
MOLECULAR WEIGHT        : 332.91
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Triprolidine hydrochloride monohydrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 840 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCTR** National Center for Toxicology Research Technical Report.  Office of
   Associate Director for Scientific Coordination, Jefferson, Arkansas 72079
   Volume(issue)/page/year: #414/415,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 163 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCTR** National Center for Toxicology Research Technical Report.  Office of
   Associate Director for Scientific Coordination, Jefferson, Arkansas 72079
   Volume(issue)/page/year: #414/415,1991
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10760 mg/kg/90D-I
TOXIC EFFECTS :
   Cardiac - changes in heart weight
   Gastrointestinal - changes in structure or function of salivary glands
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 12,359,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 103 gm/kg/2Y-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Endocrine - changes in spleen weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   27,223,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 gm/kg/2Y-C
TOXIC EFFECTS :
   Liver - other changes
   Liver - changes in liver weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NCTR** National Center for Toxicology Research Technical Report.  Office of
   Associate Director for Scientific Coordination, Jefferson, Arkansas 72079
   Volume(issue)/page/year: #414/415,1991

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X2762
       No. of Facilities: 269 (estimated)
       No. of Industries: 1
       No. of Occupations: 4
       No. of Employees: 4419 (estimated)
       No. of Female Employees: 2546 (estimated)

 
                            *** END OF RECORD ***