*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UT7657000
CHEMICAL NAME           : Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-,
                          monohydrochloride, (E)-
CAS REGISTRY NUMBER     : 550-70-9
LAST UPDATED            : 199803
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C19-H22-N2.Cl-H
MOLECULAR WEIGHT        : 314.89
WISWESSER LINE NOTATION : T6NJ BYR D1&2- AT5NTJ &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Actidil
   * Actidilat
   * 295 C 51
   * Entra
   * trans-1-(4'-Methylphenyl)-1-(2'-pyridyl)-3-pyrrolidinoprop-1-N E  
   hydrochloride
   * Pro-Actidil
   * Pro-Entra
   * Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-,  
   monohydrochloride, (E)-
   * trans-2-(3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)pyridine monohydrochloride
   * Triprolidine hydrochloride
   * Venen
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 840 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 22,375,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 495 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,525,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 247 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,525,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 8,171,1953
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >5 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 8,171,1953

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 81570
       No. of Facilities: 842 (estimated)
       No. of Industries: 2
       No. of Occupations: 2
       No. of Employees: 990 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 81570
       No. of Facilities: 178 (estimated)
       No. of Industries: 1
       No. of Occupations: 3
       No. of Employees: 2378 (estimated)
       No. of Female Employees: 1467 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***