*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : US7201200
CHEMICAL NAME           : 3,5-Pyridinedicarboxylic acid,
                          1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(4-
                          (diphenylmethyl)-1-piperazinyl)phenyl)ethyl methyl
                          ester, dihydrochloride, (S)-(+)-
CAS REGISTRY NUMBER     : 189624-85-9
LAST UPDATED            : 199806
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C41-H42-N4-O6.2Cl-H
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (S)-AE0047
   * (S)-(+)-AE 0047
   * (S)-(+)-Watanidipine hydrochloride
   * Watanidipine hydrochloride (S)-enantiomer
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >12 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - conjunctive irritation
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 25(Suppl 3),S745,1997
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 14850 ug/kg/9D-I
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), diffuse
   Blood - normocytic anemia
   Related to Chronic Data - death
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 25(Suppl 3),S793,1997
 
                            *** END OF RECORD ***