*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : US7961300
CHEMICAL NAME           : 2,4-Pyridinedicarboxamide, N,N'-bis(2-methoxyethyl)-
CAS REGISTRY NUMBER     : 128075-79-6
LAST UPDATED            : 199409
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C13-H19-N3-O4
MOLECULAR WEIGHT        : 281.35
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N,N'-Bis(2-methoxyethyl)-2,4-pyridinedicarboxamide
   * HOE 077
   * Lufironil
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOHEEC Journal of Hepathology.  (Elsevier Science, 655 Avenue of the
   Americas, New York, NY  10010)  V.1-    1985-  Volume(issue)/page/year:
   13(Suppl 3),63,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOHEEC Journal of Hepathology.  (Elsevier Science, 655 Avenue of the
   Americas, New York, NY  10010)  V.1-    1985-  Volume(issue)/page/year:
   13(Suppl 3),63,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOHEEC Journal of Hepathology.  (Elsevier Science, 655 Avenue of the
   Americas, New York, NY  10010)  V.1-    1985-  Volume(issue)/page/year:
   13(Suppl 3),63,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOHEEC Journal of Hepathology.  (Elsevier Science, 655 Avenue of the
   Americas, New York, NY  10010)  V.1-    1985-  Volume(issue)/page/year:
   13(Suppl 3),63,1991
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 455 gm/kg/26W-I
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   JOHEEC Journal of Hepathology.  (Elsevier Science, 655 Avenue of the
   Americas, New York, NY  10010)  V.1-    1985-  Volume(issue)/page/year:
   13(Suppl 3),63,1991
 
                            *** END OF RECORD ***