*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : US6379500
CHEMICAL NAME           : Pyridine,
                          2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-
CAS REGISTRY NUMBER     : 132-22-9
LAST UPDATED            : 199701
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C16-H19-Cl-N2
MOLECULAR WEIGHT        : 274.82
WISWESSER LINE NOTATION : T6NJ BYR DG&2N1&1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Allergican
   * Allergisan
   * 2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine
   * 4-Chloropheniramine
   * Chlorophenylpyridamine
   * 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
   * 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine
   * Chloropiril
   * Chloroprophenpyridamine
   * Chlorphenamine
   * Chlorpheniramine
   * Chlorprophenpyridamine
   * Clorfeniramina
   * Cloropiril
   * Haynon
   * Histadur
   * Polaronil
   * 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 118 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MEWEAC Medizinische Welt.  (F.K. Schattauer Verlag, Postfach 2945, D-7000
   Stuttgart 1, Fed. Rep. Ger.)  V.1-18, 1927-1944; V.1-    1950-
   Volume(issue)/page/year: 17,2791,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 121 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MEWEAC Medizinische Welt.  (F.K. Schattauer Verlag, Postfach 2945, D-7000
   Stuttgart 1, Fed. Rep. Ger.)  V.1-18, 1927-1944; V.1-    1950-
   Volume(issue)/page/year: 17,2791,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 92,1339,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   111,293,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MEWEAC Medizinische Welt.  (F.K. Schattauer Verlag, Postfach 2945, D-7000
   Stuttgart 1, Fed. Rep. Ger.)  V.1-18, 1927-1944; V.1-    1950-
   Volume(issue)/page/year: 17,2791,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MEWEAC Medizinische Welt.  (F.K. Schattauer Verlag, Postfach 2945, D-7000
   Stuttgart 1, Fed. Rep. Ger.)  V.1-18, 1927-1944; V.1-    1950-
   Volume(issue)/page/year: 17,2791,1966

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 17,85,1980

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***