*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : US5908290
CHEMICAL NAME           : 3-Pyridinecarboxylic acid,
                          1,2,5,6-tetrahydro-1-(2-(bis(4-(trifluoromethyl)pheny
                          l)methoxy) ethyl)-, hydrochloride
CAS REGISTRY NUMBER     : 110283-66-4
LAST UPDATED            : 199403
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C23-H21-F6-N-O3.Cl-H
MOLECULAR WEIGHT        : 509.91
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * CI 966
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 894 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - coma
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   DDREDK Drug Development Research.  (Alan R. Liss, Inc., 41 E. 11th St., New
   York, NY 10003) V.1-    1981-  Volume(issue)/page/year: 28,65,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 703 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - hypermotility, diarrhea
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   DDREDK Drug Development Research.  (Alan R. Liss, Inc., 41 E. 11th St., New
   York, NY 10003) V.1-    1981-  Volume(issue)/page/year: 28,65,1993
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14 gm/kg/4W-C
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Endocrine - hyperglycemia
   Related to Chronic Data - death
REFERENCE :
   DDREDK Drug Development Research.  (Alan R. Liss, Inc., 41 E. 11th St., New
   York, NY 10003) V.1-    1981-  Volume(issue)/page/year: 28,65,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 420 mg/kg/4W-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   DDREDK Drug Development Research.  (Alan R. Liss, Inc., 41 E. 11th St., New
   York, NY 10003) V.1-    1981-  Volume(issue)/page/year: 28,65,1993
 
                            *** END OF RECORD ***