*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : US4040000
CHEMICAL NAME           : Pyridine,
                          2-((5-bromo-2-thenyl)(2-(dimethylamino)ethyl)amino)-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 5801-12-7
LAST UPDATED            : 198708
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C14-H18-Br-N3-S.Cl-H
MOLECULAR WEIGHT        : 376.78
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Bromothen hydrochloride
   * N,N-Dimethyl-N'-(2-pyridyl)-N'-(5-bromo-2-thenyl)ethylenediamine  
   hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 476 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JHHBAI Bulletin of the Johns Hopkins Hospital.  (Baltimore, MD)  V.1-119,
   1889-1966.  For publisher information, see JHMJAX. Volume(issue)/page/year:
   81,55,1947
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 144 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JHHBAI Bulletin of the Johns Hopkins Hospital.  (Baltimore, MD)  V.1-119,
   1889-1966.  For publisher information, see JHMJAX. Volume(issue)/page/year:
   81,55,1947
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JHHBAI Bulletin of the Johns Hopkins Hospital.  (Baltimore, MD)  V.1-119,
   1889-1966.  For publisher information, see JHMJAX. Volume(issue)/page/year:
   81,55,1947
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 87500 ug/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JHHBAI Bulletin of the Johns Hopkins Hospital.  (Baltimore, MD)  V.1-119,
   1889-1966.  For publisher information, see JHMJAX. Volume(issue)/page/year:
   81,55,1947
 
                            *** END OF RECORD ***