*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : US4600000
CHEMICAL NAME           : 3-Pyridinecarboxamide,
                          1,2-dihydro-2-oxo-N-(2,6-xylyl)-
CAS REGISTRY NUMBER     : 57021-61-1
LAST UPDATED            : 199210
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C14-H14-N2-O2
MOLECULAR WEIGHT        : 242.30
WISWESSER LINE NOTATION : T6MVJ CVMR B1 F1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1,2-Dihydroxy-2-oxo-N-(2,6-xylyl)-3-pyridinecarboxamide
   * 2-Hydroxy-2',6'-nicotinoxylidide
   * Isonixin
   * Isonixine
   * Nixyn
   * Nixyn hermes
   * 3-Pyridinecarboxamide, N-(2,6-dimethylphenyl)-1,2-dihydro-2-oxo-
   * 2,6-Xylidide of 2-pyridone-3-carboxylic acid
   * 2,6-Xylidid der 2-pyridon-3-carboxylsaure
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >6 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,1457,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,1457,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,1457,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,1457,1977
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 281 gm/kg/26W-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Related to Chronic Data - death
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,1460,1977
 
                            *** END OF RECORD ***