*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : US4356000
CHEMICAL NAME           : 3-Pyridinecarboxaldehyde,
                          1,2,5,6-tetrahydro-1-methyl-, O-methyloxime,
                          monohydrochloride, (E)-
CAS REGISTRY NUMBER     : 139886-04-7
OTHER CAS REGISTRY NOS. : 147414-43-5
LAST UPDATED            : 199704
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C8-H14-N2-O.Cl-H
MOLECULAR WEIGHT        : 190.70
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * CI 979
   * Milameline hydrochloride
   * RU 35926
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 26,853,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 26,853,1991
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 140 mg/kg/14D-I
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Kidney, Ureter, Bladder - other changes
   Related to Chronic Data - death
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   34,407,1996
 
                            *** END OF RECORD ***