*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UR6475100
CHEMICAL NAME           : 3(2H)-Pyridazinone,
                          4,5-dihydro-6-(2-(4-pyridinyl)ethenyl)-, (E)-
CAS REGISTRY NUMBER     : 87164-90-7
LAST UPDATED            : 199403
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C11-H11-N3-O
MOLECULAR WEIGHT        : 201.25
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (E)-4,5-Dihydro-6-(2-(4-pyridinyl)ethenyl)-3(2H)-pyridazinone
   * ICI 153110
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7 gm/kg/28D-I
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Nutritional and Gross Metabolic - body temperature decrease
   Related to Chronic Data - death
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   14,797,1990
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 45500 mg/kg/26W-I
TOXIC EFFECTS :
   Vascular - structural changes in vessels
   Vascular - other changes
   Related to Chronic Data - death
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   14,797,1990
 
                            *** END OF RECORD ***