*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UR6373010
CHEMICAL NAME           : 3(2H)-Pyridazinone,
                          4,5-dihydro-6-(2-(4-methoxyphenyl)-1H-benzimidazol-5-
                          yl)-5-methyl-, (-)-
CAS REGISTRY NUMBER     : 118428-37-8
BEILSTEIN REFERENCE NO. : 4207330
LAST UPDATED            : 199706
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H18-N4-O2
MOLECULAR WEIGHT        : 334.41
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   (-)-4,5-Dihydro-6-(2-(4-methoxyphenyl)-1H-benzimidazol-5-yl)-5-methyl-3(
     2H)-pyridazinone
   * (-)-Pimobendan
   * l-Pimobendan
   * (-)-UD-CG 115BS
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 43,561,1992
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 7 mg/kg/4W-I
TOXIC EFFECTS :
   Cardiac - other changes
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 43,561,1992
 
                            *** END OF RECORD ***