*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UR6040000
CHEMICAL NAME           : Pyridazine,
                          3-hydrazino-6-((2-hydroxypropyl)methylamino)-,
                          dihydrochloride
CAS REGISTRY NUMBER     : 56393-22-7
LAST UPDATED            : 199112
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C8-H15-N5-O.2Cl-H
MOLECULAR WEIGHT        : 270.20
WISWESSER LINE NOTATION : T6NNJ CMZ F1M1YQ1 &GH 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Atensil
   * 3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride
   * 6-((2-Hydroxypropyl)methylamino)-3(2H)-pyridazinone hydrazone  
   dihydrochloride
   * 3-Idrazino-6-(N-(2-idrossipropil)metilamino)piridazina dicloridrato
   * ISF 2123
   * Pildralazine dihydrochloride
   * Propildazina
   * Propildazine hydrochloride
   * Propyldazine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1230 mg/kg
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   PLRCAT Pharmacological Research Communications.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1969-  Volume(issue)/page/year:
   8,295,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 355 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PLRCAT Pharmacological Research Communications.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1969-  Volume(issue)/page/year:
   8,295,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1170 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PLRCAT Pharmacological Research Communications.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1969-  Volume(issue)/page/year:
   8,295,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 357 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PLRCAT Pharmacological Research Communications.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1969-  Volume(issue)/page/year:
   8,295,1976
 
                            *** END OF RECORD ***