*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UR5808000
CHEMICAL NAME           : Pyridazine, 3-amino-6-(2-(5-nitro-2-furyl)vinyl)-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 50832-74-1
LAST UPDATED            : 198812
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C10-H8-N4-O3.Cl-H
MOLECULAR WEIGHT        : 268.68
WISWESSER LINE NOTATION : T6NNJ CZ F1U1- BT5OJ ENW &GH
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * 3-Amino-6-(2-(5-nitro-2-furyl)vinyl)pyridazine hydrochloride
   * Carofur
   * Nifurprazine hydrochloride
   * Nifurprazinium
   * (1-(5-Nitro-2-furyl)-2-(6-amino-3-pyridazyl)ethylene) hydrochloride
   * 3-Pyridazinamine, 6-(2-(5-nitro-2-furanyl)ethenyl)-, monohydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 1000 ppm
REFERENCE :
   MGGEAE Molecular and General Genetics.  (Springer-Verlag, Heidelberger Pl.
   3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.99-    1967-
   Volume(issue)/page/year: 139,255,1975
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 20 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 59,139,1979
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 200 ug/L/72H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 59,139,1979
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 20 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 42,109,1977
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 2 mg/L/72H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 59,139,1979
 
TYPE OF TEST            : Body fluid assay
TEST SYSTEM             : Rodent - rat Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 500 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 67,145,1979
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 20 ppm/2H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 42,109,1977
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 5 ppm/24H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 42,109,1977

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S
   cerevisiae-homozygosis
   
   EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay

 
                            *** END OF RECORD ***