*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UR0370000
CHEMICAL NAME           : 3H-Pyrazol-3-one,
                          5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-2,4-dihydro-
CAS REGISTRY NUMBER     : 55294-15-0
OTHER CAS REGISTRY NOS. : 37296-93-8
BEILSTEIN REFERENCE NO. : 0660881
LAST UPDATED            : 199703
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C11-H11-Cl2-N3-O
MOLECULAR WEIGHT        : 272.15
WISWESSER LINE NOTATION : T5NNV DHJ BY1&R CG DG& EZ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 3-Amino-1-(3,4-dichloro-alpha-methylbenzyl)-2-pyrazolin-5-one
   * 5-Amino-2-(1-(3,4-dichlorophenyl)-ethyl)-2,4-dihydro-3H-pyrazol-3-one
   * BAY G 2821
   * Edrul
   * 3H-Pyrazol-3-one, 2,4-dihydro-5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-
   * Muzolimina
   * Muzolimine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1559 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory obstruction
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   CMROCX Current Medical Research and Opinion.  (Clayton-Wray Pub. Ltd., 1a
   High St., Alton, Hants., UK)  V.1-    1972-  Volume(issue)/page/year:
   4,716,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 221 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   CLNHBI Clinical Nephrology.  (Dustri-Verlag Dr. Karl Feistle, Postfach 49,
   D-8024 Munich-Deisenhofen, Fed. Rep. Ger.)  V.1-    1973-
   Volume(issue)/page/year: 19(Suppl 1),20,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1794 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory obstruction
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   CMROCX Current Medical Research and Opinion.  (Clayton-Wray Pub. Ltd., 1a
   High St., Alton, Hants., UK)  V.1-    1972-  Volume(issue)/page/year:
   4,716,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   CLNHBI Clinical Nephrology.  (Dustri-Verlag Dr. Karl Feistle, Postfach 49,
   D-8024 Munich-Deisenhofen, Fed. Rep. Ger.)  V.1-    1973-
   Volume(issue)/page/year: 19(Suppl 1),20,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Behavioral - fluid intake
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   CMROCX Current Medical Research and Opinion.  (Clayton-Wray Pub. Ltd., 1a
   High St., Alton, Hants., UK)  V.1-    1972-  Volume(issue)/page/year:
   4,716,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLNHBI Clinical Nephrology.  (Dustri-Verlag Dr. Karl Feistle, Postfach 49,
   D-8024 Munich-Deisenhofen, Fed. Rep. Ger.)  V.1-    1973-
   Volume(issue)/page/year: 19(Suppl 1),20,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1250 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory obstruction
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   CMROCX Current Medical Research and Opinion.  (Clayton-Wray Pub. Ltd., 1a
   High St., Alton, Hants., UK)  V.1-    1972-  Volume(issue)/page/year:
   4,716,1977
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9 gm/kg/13W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - urine volume increased
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   CMROCX Current Medical Research and Opinion.  (Clayton-Wray Pub. Ltd., 1a
   High St., Alton, Hants., UK)  V.1-    1972-  Volume(issue)/page/year:
   4,716,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1620 mg/kg/13W-I
TOXIC EFFECTS :
   Behavioral - fluid intake
   Kidney, Ureter, Bladder - urine volume increased
   Related to Chronic Data - death
REFERENCE :
   CMROCX Current Medical Research and Opinion.  (Clayton-Wray Pub. Ltd., 1a
   High St., Alton, Hants., UK)  V.1-    1972-  Volume(issue)/page/year:
   4,716,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 84 mg/kg/4W-I
TOXIC EFFECTS :
   Behavioral - fluid intake
   Kidney, Ureter, Bladder - urine volume increased
   Nutritional and Gross Metabolic - dehydration
REFERENCE :
   CMROCX Current Medical Research and Opinion.  (Clayton-Wray Pub. Ltd., 1a
   High St., Alton, Hants., UK)  V.1-    1972-  Volume(issue)/page/year:
   4,716,1977
 
                            *** END OF RECORD ***