*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : UQ6400000
CHEMICAL NAME : Pyrazole-3-carboxylic acid,
5-hydroxy-1-(p-sulfophenyl)-4-(p-sulfophenyl)azo-,
trisodium salt
CAS REGISTRY NUMBER : 1934-21-0
LAST UPDATED : 199710
DATA ITEMS CITED : 23
MOLECULAR FORMULA : C16-H9-N4-O9-S2.3Na
MOLECULAR WEIGHT : 534.38
WISWESSER LINE NOTATION : T5NNJ AR DSWO& CVO DNUNR DSWO& EQ &-NA- 3
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Acid Leather Yellow T
* Acid Yellow 23
* Acid Yellow T
* Acilan Yellow GG
* A.F. Yellow No. 4
* Airedale Yellow T
* Aizen tartrazine
* Amacid Yellow T
* Atul Tartrazine
* Bucacid tartrazine
* Calcocid Yellow MCG
* Calcocid Yellow XX
* Canacert tartrazine
* 3-Carboxy-5-hydroxy-1-p-sulfophenyl-4-p-sulfophenylazopyrazole trisodium
salt
* Certicol Tartrazol Yellow S
* Cilefa Yellow T
* C.I. 640
* C.I. 19140
* C.I. Acid Yellow 23
* C.I. Acid Yellow 23, trisodium salt
* C.I. Food Yellow 4
* Curon Fast Yellow 5G
* D and C Yellow No. 5
* Dolkwal tartrazine
* Dye FD and C Yellow No. 5
* E 102
* Edicol Supra Tartrazine N
* Egg Yellow A
* Erio Tartrazine
* Eurocert tartrazine
* FD and C Yellow 5
* FD & C Yellow No. 5 tartrazine
* Fenazo Yellow T
* Food Yellow 4
* Food Yellow 5
* HD tartrazine
* HD Tartrazine Supra
* Hexacert Yellow No. 5
* Hexacol tartrazine
* Hidazid tartrazine
* Hispacid Fast Yellow T
* Hydrazine Yellow
* Hydroxine Yellow L
* Kako tartrazine
* Kayaku Food Colour Yellow No. 4
* Kayaku tartrazine
* Kca Foodcol Tartrazine PF
* Kca Tartrazine PF
* Kiton Yellow T
* Lake Yellow
* Lemon Yellow A
* Lemon Yellow A Geigy
* L-Gelb 2
* Maple Tartrazol Yellow
* Mitsui tartrazine
* Naphtocard Yellow O
* Neklacid Yellow T
* Oxanal Yellow T
* San-ei Tartrazine
* Schultz No. 737
* Sugai tartrazine
* Tartar Yellow N
* Tartar Yellow S
* Tartar Yellow FS
* Tartar Yellow PF
* Tartran Yellow
* Tartraphenine
* Tartrazine
* Tartrazine A Export
* Tartrazine B
* Tartrazine B.P.C.
* Tartrazine Extra Pure A
* Tartrazine FD&C Yellow #5
* Tartrazine FQ
* Tartrazine G
* Tartrazine Lake
* Tartrazine Lake Yellow N
* Tartrazine M
* Tartrazine MCGL
* Tartrazine N
* Tartrazine NS
* Tartrazine O
* Tartrazine T
* Tartrazine XX
* Tartrazine XXX
* Tartrazine Yellow
* Tartrazol BPC
* Tartrazol Yellow
* Tartrine Yellow O
* Trisodium 3-carboxy-5-hydroxy-1-p-sulfophenyl-4-p-sulfophenylazopyrazole
* Trisodium salt of 3-carboxy-5-hydroxy-1-sulfophenylazopyrazole
* Unitertracid Yellow TE
* Usacert Yellow No. 5
* Vondacid tartrazine
* Wool Yellow
* Xylene Fast Yellow GT
* Y-4
* 1310 Yellow
* 1409 Yellow
* Yellow Lake 69
* Yellow No. 5
* Yellow No. 5 FDC
* Zlut kysela 23
* Zlut pigment 100
* Zlut potravinarska 4
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 14 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis
Musculoskeletal - changes in teeth and supporting structures
REFERENCE :
ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671,
Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 17,719,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 38B,88,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil,
France) V.1- 1943- Volume(issue)/page/year: 15,402,1957
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 12750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 38B,88,1966
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 476 mg/kg/28D-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 10,625,1958
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 18500 mg/kg
SEX/DURATION : female 7-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 2,1211,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1280 mg/kg
SEX/DURATION : female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 24,399,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 20 gm/kg
SEX/DURATION : female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 24,399,1982
** MUTATION DATA **
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 600 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 224,479,1989
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 100 mg/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year:
11,528,1975
TYPE OF TEST : Body fluid assay
TEST SYSTEM : Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION : 1500 mg/kg
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
60,328,1987
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 2500 mg/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
22,623,1984
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 2100 mg/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring
St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year:
27,95,1981
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Mammal - species unspecified Fibroblast
DOSE/DURATION : 5 mg/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
20,461,1982
*** REVIEWS ***
TOXICOLOGY REVIEW
DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH
45242) V.3- 1969- Volume(issue)/page/year: 9,198,1975
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2148
No. of Facilities: 2666 (estimated)
No. of Industries: 32
No. of Occupations: 45
No. of Employees: 47875 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M2148
No. of Facilities: 15429 (estimated)
No. of Industries: 95
No. of Occupations: 99
No. of Employees: 318163 (estimated)
No. of Female Employees: 157622 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***