*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UQ4730325
CHEMICAL NAME           : 2H,10H-Pyrazino(1,2-alpha)pyrrolo(2,1-c)(1,4)benzodia
                          zepine, 1,3,4,14b-tetrahydro-2-methyl-,
                          (Z)-2-butenedioate (1:1)
CAS REGISTRY NUMBER     : 71576-41-5
LAST UPDATED            : 199512
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C16-H19-N3.C4-H4-O4
MOLECULAR WEIGHT        : 369.46
SYNONYMS/TRADE NAMES :
   * Aptazapine maleate
   * CGS 7525A
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 43680 mg/kg/2Y-I
TOXIC EFFECTS :
   Cardiac - other changes
   Endocrine - other changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 6,46,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 32760 mg/kg/78W-I
TOXIC EFFECTS :
   Cardiac - other changes
   Liver - other changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 6,46,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1092 mg/kg/52W-I
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Liver - other changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 6,46,1986
 
                            *** END OF RECORD ***