*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UQ3950000
CHEMICAL NAME           : 1H-Pyrazino(3,2,1-jk)carbazole,
                          2,3,3a,4,5,6-hexahydro-, monohydrochloride
CAS REGISTRY NUMBER     : 16154-77-1
LAST UPDATED            : 199312
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C14-H16-N2.Cl-H
MOLECULAR WEIGHT        : 248.78
WISWESSER LINE NOTATION : T C6566 1A P BN NM&&TTJ &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 2,3,3a,4,5,6-Hexahydro-1H-pyrazino(3,2,1-jk)carbazole hydrochloride
   * Piperazino(1,2-a)indole, 1,10-trimethylene-, hydrochloride
   * 1,10-Trimethylene-pyrazino-indole hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 138 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - antipsychotic
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 31,155,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 285 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - muscle contraction or spasticity
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 10,1471,1976
 
                            *** END OF RECORD ***