*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UP7525000
CHEMICAL NAME           : Pyran-3,4-dicarboxylic anhydride,
                          tetrahydro-2-methyl-6-(tetrahydro-2,5-dioxo-3-furyl)-
                          , polymer
CAS REGISTRY NUMBER     : 26427-28-1
LAST UPDATED            : 199606
DATA ITEMS CITED        : 6
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * NSC-46015
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
   D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
   Volume(issue)/page/year: -,38,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 121 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
   D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
   Volume(issue)/page/year: -,38,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 106 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
   D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
   Volume(issue)/page/year: -,38,1964
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 112 mg/kg/28D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in both tubules and glomeruli
   Skin and Appendages - dermatitis, other (after systemic exposure)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
   D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
   Volume(issue)/page/year: -,38,1964
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 448 mg/kg/28D-I
TOXIC EFFECTS :
   Liver - other changes
   Kidney, Ureter, Bladder - other changes
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
   D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
   Volume(issue)/page/year: -,38,1964
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - mouse Liver
DOSE/DURATION           : 2 gm/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   38,1610,1978
 
                            *** END OF RECORD ***