*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UP0175000
CHEMICAL NAME           : 9H-Purine-6-thiol,
                          2-amino-9-(2-deoxy-beta-D-erytho-pentofuranosyl)-,
                          monohydrate
CAS REGISTRY NUMBER     : 64039-27-6
LAST UPDATED            : 199707
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C10-H13-N5-O3-S.H2-O
MOLECULAR WEIGHT        : 301.36
WISWESSER LINE NOTATION : T56 BN DN FN HNJ GZ ISH D- BT5OTJ CQ DQ E1 &QH
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * beta-Deoxythioguanosine monohydrate
   * beta-2'-Deoxy-6-thioguanosine monohydrate
   * Guanosine, 2'-deoxy-6-thio-, monohydrate
   * NSC-71261
   * 9H-Purine-6-thiol, 2-amino-9-(2-deoxy-beta-D-ribofuranosyl)-, hydrate
   * beta-TGdR monohydrate
   * beta-Thioguanine deoxyriboside monohydrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 467 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - conjunctive irritation
   Behavioral - tremor
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,522,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 354 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - conjunctive irritation
   Behavioral - tremor
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,522,1969
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 142 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Lungs, Thorax, or Respiration - other changes
   Endocrine - hyperglycemia
REFERENCE :
   CCYPBY Cancer Chemotherapy Reports, Part 3.  (Washington, DC)  V.1-6,
   1968-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   4,41,1973
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg/5D-I
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Related to Chronic Data - death
REFERENCE :
   CCYPBY Cancer Chemotherapy Reports, Part 3.  (Washington, DC)  V.1-6,
   1968-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   4,41,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 75 mg/kg/5D-I
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Related to Chronic Data - death
REFERENCE :
   CCYPBY Cancer Chemotherapy Reports, Part 3.  (Washington, DC)  V.1-6,
   1968-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   4,41,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 13500 ug/kg/5D-I
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from stomach
   Gastrointestinal - ulceration or bleeding from large intestine
   Blood - leukopenia
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,522,1969
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 17760 ug/kg/2W-I
TOXIC EFFECTS :
   Endocrine - other changes
   Blood - changes in bone marrow (not otherwise specified)
   Related to Chronic Data - death
REFERENCE :
   CCYPBY Cancer Chemotherapy Reports, Part 3.  (Washington, DC)  V.1-6,
   1968-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   4,41,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 39200 ug/kg/14D-I
TOXIC EFFECTS :
   Blood - normocytic anemia
   Blood - leukopenia
   Related to Chronic Data - death
REFERENCE :
   CCYPBY Cancer Chemotherapy Reports, Part 3.  (Washington, DC)  V.1-6,
   1968-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   4,41,1973
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1092 mg/kg/1Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Ear) - effect, not otherwise specified
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-57,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   33,3069,1973
 
                            *** END OF RECORD ***