*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UO8440545
CHEMICAL NAME           : 1H-Purine-2,6-dione,
                          7-((4-(dimethylamino)phenyl)methyl)-3,7-dihydro-1,3-d
                          imethyl-, monohydrochloride
CAS REGISTRY NUMBER     : 1703-49-7
LAST UPDATED            : 199704
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C16-H19-N5-O2.Cl-H
MOLECULAR WEIGHT        : 349.86
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (p-Dimethylamino benzyl)-7 dimethyl-1,3 xanthine chlorhydrate
   * p-Dimethylamino-benzyl theophylline chlorhydrate
   * LJ 278
   * Theophylline, 7-(p-(dimethylamino)benzyl)-, hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 660 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMXXAJ French Medicament Patent Document.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Discontinued.
   Volume(issue)/page/year: #3586M
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 630 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMXXAJ French Medicament Patent Document.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Discontinued.
   Volume(issue)/page/year: #3586M
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 82500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMXXAJ French Medicament Patent Document.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Discontinued.
   Volume(issue)/page/year: #3586M
 
                            *** END OF RECORD ***