*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BZ6260000
CHEMICAL NAME           : p-Anisidine, 3-chloro-
CAS REGISTRY NUMBER     : 5345-54-0
BEILSTEIN REFERENCE NO. : 0879162
REFERENCE               : 3-13-00-01180 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C7-H8-Cl-N-O
MOLECULAR WEIGHT        : 157.61
WISWESSER LINE NOTATION : ZR CG DO1
COMPOUND DESCRIPTOR     : Primary Irritant
SYNONYMS/TRADE NAMES :
   * Benzenamine, 3-chloro-4-methoxy-
   * 3-Chloroanisidine
   * 3-Chloro-4-methoxybenzenamine
   * OCPA
   * Orthochloroparanisidine
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/24H
REACTION SEVERITY       : Mild
REFERENCE :
   TOERD9 Toxicological European Research.  (S.P.E., 10, Ave. de Messine, 75008
   Paris, France) V.1-    1978-  Volume(issue)/page/year: 2,77,1979
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg
REACTION SEVERITY       : Mild
REFERENCE :
   TOERD9 Toxicological European Research.  (S.P.E., 10, Ave. de Messine, 75008
   Paris, France) V.1-    1978-  Volume(issue)/page/year: 2,77,1979
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 550 mg/kg
TOXIC EFFECTS :
   Liver - other changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   TOERD9 Toxicological European Research.  (S.P.E., 10, Ave. de Messine, 75008
   Paris, France) V.1-    1978-  Volume(issue)/page/year: 2,77,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 510 mg/kg
TOXIC EFFECTS :
   Liver - other changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   TOERD9 Toxicological European Research.  (S.P.E., 10, Ave. de Messine, 75008
   Paris, France) V.1-    1978-  Volume(issue)/page/year: 2,77,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 650 mg/kg
TOXIC EFFECTS :
   Liver - other changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   TOERD9 Toxicological European Research.  (S.P.E., 10, Ave. de Messine, 75008
   Paris, France) V.1-    1978-  Volume(issue)/page/year: 2,77,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 670 mg/kg
TOXIC EFFECTS :
   Liver - other changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   TOERD9 Toxicological European Research.  (S.P.E., 10, Ave. de Messine, 75008
   Paris, France) V.1-    1978-  Volume(issue)/page/year: 2,77,1979
 
                            *** END OF RECORD ***