*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BW8225000
CHEMICAL NAME           : Aniline, N,N-bis(2-chloroethyl)-
CAS REGISTRY NUMBER     : 553-27-5
BEILSTEIN REFERENCE NO. : 0880463
REFERENCE               : 4-12-00-00253 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C10-H13-Cl2-N
MOLECULAR WEIGHT        : 218.14
WISWESSER LINE NOTATION : G2NR&2G
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Aniline mustard
   * Anilinlost
   * N,N-Bis(2-chloroethyl)aniline
   * N,N-Bis(2-chloroethyl)benzenamine
   * beta,beta'-Dichlorodiethylaniline
   * N,N,-Di(2-chloroethyl)aniline
   * Lymphchin
   * Lymphocin
   * Lymphoquin
   * NSC-18429
   * Phenylbis(2-chloroethylamine)
   * TL 476
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 239 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCIMR* Progress Report Submitted to the National Cancer Institute by Mason
   Research Institute. (Worcester, MA)  Volume(issue)/page/year: -,469,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 8,167,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 123 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCIMR* Progress Report Submitted to the National Cancer Institute by Mason
   Research Institute. (Worcester, MA)  Volume(issue)/page/year: -,469,1969
 
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/m3/10M
TOXIC EFFECTS :
   Behavioral - irritability
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   NDRC** National Defense Research Committee, Office of Scientific Research
   and Development, Progress Report.  Volume(issue)/page/year:
   NDCrc-132,DEC1942
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 52 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCIMR* Progress Report Submitted to the National Cancer Institute by Mason
   Research Institute. (Worcester, MA)  Volume(issue)/page/year: -,469,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHUZBI Pharmazie in Unserer Zeit.  (VCH Pub., Inc., 303 N.W. 12th Ave.,
   Deerfield Beach, FL 33441) V.1-    1972-  Volume(issue)/page/year: 5,41,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHBUA9 Pharmaceutical Bulletin.  (Tokyo, Japan)  V.1-5, 1953-57.  For
   publisher information, see CPBTAL.  Volume(issue)/page/year: 5,203,1957
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 375 mg/kg/35D-I
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NCIMR* Progress Report Submitted to the National Cancer Institute by Mason
   Research Institute. (Worcester, MA)  Volume(issue)/page/year: -,469,1969
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 375 mg/kg/15D-I
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - changes in bone marrow (not otherwise specified)
   Related to Chronic Data - death
REFERENCE :
   NCIMR* Progress Report Submitted to the National Cancer Institute by Mason
   Research Institute. (Worcester, MA)  Volume(issue)/page/year: -,469,1969
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 30 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   44,78,1984

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal

 
                            *** END OF RECORD ***