*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BV8518400
CHEMICAL NAME           : Androst-4-en-3-one, 17-hydroxy-, (17-beta)-, mixt
                          with (17-beta)-1,3,5(10)-triene-3,17-diol
CAS REGISTRY NUMBER     : 8055-33-2
LAST UPDATED            : 199806
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H28-O2.C18-H24-O2
MOLECULAR WEIGHT        : 560.89
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Estradiol-testosterone mixt.
   * Testosterone-17-beta-estradiol mixt.
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,806,1995
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 9849 ug/kg
SEX/DURATION            : male 98 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 27,383,1983
 
                            *** END OF RECORD ***