*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BV8089710
CHEMICAL NAME           : Androst-5-ene-3-alpha,17-beta-diamine,
                          dihydrochloride
CAS REGISTRY NUMBER     : 3346-27-8
LAST UPDATED            : 198402
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H32-N2.2Cl-H
MOLECULAR WEIGHT        : 361.45
COMPOUND DESCRIPTOR     : Drug
                          Hormone
SYNONYMS/TRADE NAMES :
   * Chlorhydrate de diamino-3-alpha 17-beta androstene-5
   * 3-alpha,17-beta-Diaminoandrost-5-ene dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 25,749,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 25,749,1967
 
                            *** END OF RECORD ***