*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BV8053000
CHEMICAL NAME           : 5-alpha-Androstan-17-one, 3-alpha-hydroxy-
CAS REGISTRY NUMBER     : 53-41-8
BEILSTEIN REFERENCE NO. : 2217626
REFERENCE               : 4-08-00-00642 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C19-H30-O2
MOLECULAR WEIGHT        : 290.49
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Androstan-17-one, 3-hydroxy-, (3-alpha,5-alpha)-
   * Androstanon-3-alpha-ol-17-one
   * 5-alpha-Androstan-3-alpha-ol-17-one
   * Androsterone
   * cis-Androsterone
   * 3-Epihydroxyetioallocholan-17-one
   * 3-alpha-Hydroxy-17-androstanone
   * 3-alpha-Hydroxy-5-alpha-androstan-17-one
   * 3-alpha-Hydroxyetioallocholan-17-one
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 8400 ug/kg
SEX/DURATION            : male 21 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   21,313,1937
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 80 mg/kg
SEX/DURATION            : female 13-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   99,1490,1976

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X3818
       No. of Facilities: 53 (estimated)
       No. of Industries: 2
       No. of Occupations: 2
       No. of Employees: 767 (estimated)
       No. of Female Employees: 347 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse

 
                            *** END OF RECORD ***