*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UO8413250
CHEMICAL NAME           : 1H-Purine-2,6-dione,
                          3,7-dihydro-7-(2-(((4-chlorophenyl)-4-pyridinylmethyl
                          )amino)ethyl)- 1,3-dimethyl-, trihydrochloride
LAST UPDATED            : 199112
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H21-Cl-N6-O2.3Cl-H
MOLECULAR WEIGHT        : 534.31
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 7-(4-Aza-4'-chlorobenzidrilamminoetil)teofiline
   * 7-(2-((alpha-4-Pyridyl-p-chlorobenzyl)amino)ethyl)theophylline  
   trihydrochloride
   * Theophylline, 7-(2-((alpha-4-pyridyl-p-chlorobenzyl)amino)ethyl)-,  
   trihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 42,561,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 42,561,1987
 
                            *** END OF RECORD ***