*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UI1555000
CHEMICAL NAME           : Propylamine,
                          N,N-dimethyl-3-(dibenzo(b,e)thiepin-delta-sup(11(6H),
                          gamma))-
CAS REGISTRY NUMBER     : 113-53-1
LAST UPDATED            : 199712
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C19-H21-N-S
MOLECULAR WEIGHT        : 295.47
WISWESSER LINE NOTATION : T C676 BY IS JHJ BU3N1&1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * 3-Dibenzo(b,e)thiepin-11(6H)-ylidene-N,N-dimethyl-1-propamine
   * 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepin
   * N,N-Dimethyldibenzo(b,e)thiepin-delta-sup(11(6H),gamma)propylamine
   * Dosulepin
   * Dothiepin
   * IZ 914
   * 1-Propanamine, 3-dibenzo(b,e)thiepin-11(6H)-ylidene-N,N-dimethyl-
   * Prothiaden
   * Prothiaden spofa
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
   Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   288,1800,1984
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 4500 ug/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   2,97,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 3214 ug/kg/12D-I
TOXIC EFFECTS :
   Behavioral - changes in psychophysiological tests
REFERENCE :
   HUPSEC Human Psychopharmacology.  (John Wiley & Sons Ltd., Baffins Lane,
   Chichester, W.Sussex PO19 1UD, United Kingdom)  V.1-    1986-
   Volume(issue)/page/year: 12,337,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 2143 ug/kg/8D-I
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - hallucinations, distorted perceptions
   Behavioral - changes in psychophysiological tests
REFERENCE :
   HUPSEC Human Psychopharmacology.  (John Wiley & Sons Ltd., Baffins Lane,
   Chichester, W.Sussex PO19 1UD, United Kingdom)  V.1-    1986-
   Volume(issue)/page/year: 12,119,1997
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 31 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 32,2854,1967
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 150 mg/kg
SEX/DURATION            : male 6 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   ACNSAX Activitas Nervosa Superior.  (Avicenum, Malostranske nam. 28, Prague
   1, Czechoslovakia) V.1-    1959-  Volume(issue)/page/year: 15,114,1973
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   ACNSAX Activitas Nervosa Superior.  (Avicenum, Malostranske nam. 28, Prague
   1, Czechoslovakia) V.1-    1959-  Volume(issue)/page/year: 15,114,1973
 
TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
REFERENCE :
   ACNSAX Activitas Nervosa Superior.  (Avicenum, Malostranske nam. 28, Prague
   1, Czechoslovakia) V.1-    1959-  Volume(issue)/page/year: 15,114,1973

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal

 
                            *** END OF RECORD ***