*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : UK8026000
CHEMICAL NAME : Prosta-5,13-dien-1-oic acid,
9,11,15-trihydroxy-15-methyl-,
(5Z,9-alpha,11-alpha,13E,15S)-, compd. with
2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
CAS REGISTRY NUMBER : 58551-69-2
LAST UPDATED : 198910
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C21-H36-O5.C4-H11-N-O3
MOLECULAR WEIGHT : 489.73
WISWESSER LINE NOTATION : L5TJ AQ B2U4VQ C1U1XQ5&1 DQ &Q1XZ1Q1Q
COMPOUND DESCRIPTOR : Reproductive Effector
Human
Hormone
SYNONYMS/TRADE NAMES :
* Carboprost tromethamine
* 15(S)15-Methyl pgf2-alpha tromethamine salt
* 15(S)15-Methyl prostaglandin F2-alpha tromethamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 25100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY)
V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 131 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY)
V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - woman
DOSE : 30 ug/kg
SEX/DURATION : female 14 week(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 11,533,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 87 ug/kg
SEX/DURATION : female 15-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
REFERENCE :
APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY)
V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 87 ug/kg
SEX/DURATION : female 15-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Fertility - abortion
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY)
V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 6 mg/kg
SEX/DURATION : male 3 day(s) pre-mating
female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY)
V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 300 ug/kg
SEX/DURATION : female 9-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY)
V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978
*** END OF RECORD ***