*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UK8021500
CHEMICAL NAME           : Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-,
                          methyl ester, (5Z,9-alpha,11-alpha, 13E,15S)-
CAS REGISTRY NUMBER     : 33854-16-9
BEILSTEIN REFERENCE NO. : 1438436
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C21-H36-O5
MOLECULAR WEIGHT        : 368.57
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Dinoprost methyl ester
   * PGF2 methyl ester
   * PGF2-alpha methyl ester
   * Prostaglandin F2-alpha methyl ester
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 80 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JOPDAB Journal of Pediatrics.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63141) V.1-    1932-  Volume(issue)/page/year:
   102,620,1983
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Human - woman
DOSE                    : 80 ug/kg
SEX/DURATION            : female 7 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JOPDAB Journal of Pediatrics.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63141) V.1-    1932-  Volume(issue)/page/year:
   102,620,1983
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 480 ug/kg
SEX/DURATION            : female 4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 186,67,1973
 
                            *** END OF RECORD ***