*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UK8010000
CHEMICAL NAME           : Prosta-5,13-dien-1-oic acid,
                          15-hydroxy-9-oxo-11,16,16-trimethyl-,
                          (5Z,11-alpha,13E,15R)-
CAS REGISTRY NUMBER     : 69900-72-7
LAST UPDATED            : 199009
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C23-H38-O4
MOLECULAR WEIGHT        : 378.61
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 15-Hydroxy-9-oxo-11,16,16-trimethylprosta-5,13-dien-1-oic acid  
   (5Z,11-alpha,13E,15R)
   * Ro 21-6937
   * Ro 21-6937/000
   * Trimoprostil
   * Ulstar
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   SHRIAI Shin'yaku to Rinsho.  New Drugs and Clinics.  (Shin'yaku to Rinsho
   Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan)  V.1-    1952-
   Volume(issue)/page/year: 35,2199,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   SHRIAI Shin'yaku to Rinsho.  New Drugs and Clinics.  (Shin'yaku to Rinsho
   Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan)  V.1-    1952-
   Volume(issue)/page/year: 35,2199,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   SHRIAI Shin'yaku to Rinsho.  New Drugs and Clinics.  (Shin'yaku to Rinsho
   Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan)  V.1-    1952-
   Volume(issue)/page/year: 35,2199,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 39 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   SHRIAI Shin'yaku to Rinsho.  New Drugs and Clinics.  (Shin'yaku to Rinsho
   Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan)  V.1-    1952-
   Volume(issue)/page/year: 35,2199,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 62 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   SHRIAI Shin'yaku to Rinsho.  New Drugs and Clinics.  (Shin'yaku to Rinsho
   Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan)  V.1-    1952-
   Volume(issue)/page/year: 35,2199,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 65 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   SHRIAI Shin'yaku to Rinsho.  New Drugs and Clinics.  (Shin'yaku to Rinsho
   Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan)  V.1-    1952-
   Volume(issue)/page/year: 35,2199,1986
 
                            *** END OF RECORD ***