*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : UF1225000
CHEMICAL NAME : Propionic acid, 2,2-dichloro-, sodium salt
CAS REGISTRY NUMBER : 127-20-8
LAST UPDATED : 199710
DATA ITEMS CITED : 26
MOLECULAR FORMULA : C3-H3-Cl2-O2.Na
MOLECULAR WEIGHT : 164.95
WISWESSER LINE NOTATION : OVXGG1 &-NA-
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
SYNONYMS/TRADE NAMES :
* Antigramigna
* Basfapon
* Dalapon sodium
* Dalapon sodium salt
* 2,2-Dichloropropionic acid, sodium salt
* alpha-alpha-Dichloropropionic acid sodium salt
* 2,2-Dichlorpropionsaeure natrium
* Dowpon
* Dowpon S
* Gramevin
* Hico DCPAS
* Natriumsalz der 2,2-dichlorpropionsaure
* Omnidel
* Omnidel Spezial
* Propanoic acid, 2,2-dichloro-, sodium salt
* Propinate
* Radapon
* Sodium Dalapon
* Sodium alpha,alpha-dichloropropionate
* Sodium 2,2-dichloropropionate
* SYS 67 Omnidel
* Tafapon
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3860 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71.
Discontinued. Volume(issue)/page/year: 9,119,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de
Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France)
V.1- 1947- Volume(issue)/page/year: 14,3,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc.,
1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For
publisher information, see AGJAEP. Volume(issue)/page/year: (11),42,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English
translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1- 1967- Volume(issue)/page/year: 16(1),45,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 3400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel,"
Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 Volume(issue)/page/year:
-,-,1971/1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport
Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:
9,222,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 3400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel,"
Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 Volume(issue)/page/year:
-,-,1971/1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 5600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept.,
Midland, MI 48640) V.1- 1945- Volume(issue)/page/year: 35,25,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - domestic
DOSE/DURATION : >4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd,
eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year:
A112,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer
Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R.,
Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971 Volume(issue)/page/year:
-,86,1971
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : >20 gm/m3/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport
Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:
9,222,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 6600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C164,1991
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 57246 mg/kg/9W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in thyroid weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 32(2),7,1967
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 26 gm/kg/22W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Endocrine - other changes
Endocrine - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 32(2),7,1967
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 36500 mg/kg/2Y-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.1- 1953- Volume(issue)/page/year: 8,47,1960
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 26 gm/kg/1Y-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.1- 1953- Volume(issue)/page/year: 8,47,1960
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 200 mg/kg
REFERENCE :
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English
translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1- 1967- Volume(issue)/page/year: 16(1),45,1982
*** REVIEWS ***
TOXICOLOGY REVIEW
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year:
53,109,1974
TOXICOLOGY REVIEW
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.)
V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-GERMANY:TWA 1 ppm (6 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 1 ppm (6 mg/m3) JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83056
No. of Facilities: 534 (estimated)
No. of Industries: 4
No. of Occupations: 2
No. of Employees: 9622 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-recombination; S cerevisiae
gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***