*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UG9450000
CHEMICAL NAME           : Propiophenone, 2-diethylamino-
CAS REGISTRY NUMBER     : 90-84-6
BEILSTEIN REFERENCE NO. : 2804400
REFERENCE               : 4-14-00-00144 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C13-H19-N-O
MOLECULAR WEIGHT        : 205.33
WISWESSER LINE NOTATION : 2N2&Y1&VR
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Adiposon
   * Amfepramone
   * Amphepramone
   * Anorex
   * alpha-Benzoyltriethylamine
   * Cegramine
   * Danylen
   * Derfon
   * alpha-Diethylaminopropiophenone
   * 2-(Diethylamino)propiophenone
   * Diethylpropion
   * Diethylpropione
   * Dobesin
   * Fenyl-(1-diethylaminoethyl)keton
   * Frekentine
   * Magrene
   * Neobes
   * Nopropiophenone
   * Obesitex
   * 1-Phenyl-2-diethylamino-1-propanone
   * 1-Propanone, 2-(diethylamino)-1-phenyl-
   * Silutin
   * Tepanil
   * Tylinal
   * UR 1423
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 11 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - sympathomimetic
   Behavioral - somnolence (general depressed activity)
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 34,205,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,177,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 20,297,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 24 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JNPHAG Journal de Pharmacologie.  (SPPIF, B.P.22, F-41353 Vineuil, France)
   V.1-    1970-  Volume(issue)/page/year: 17,37,1986
 
                            *** END OF RECORD ***