*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UG5350000
CHEMICAL NAME           : Propionohydroxamic acid, 2-(p-isobutylphenyl)-, D,L-
CAS REGISTRY NUMBER     : 73826-33-2
BEILSTEIN REFERENCE NO. : 2267673
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C13-H19-N-O2
MOLECULAR WEIGHT        : 221.33
WISWESSER LINE NOTATION : QMVY1&R D1Y1&1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * G-277
   * D,L-N-Hydroxy-alpha-methyl-4-(2-methylpropyl)benzeneacetamide
   * Ibudros
   * Ibuproxam
   * D,L-2-(4-Isobutylphenyl)propiohydroxamic acid
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   20,475,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 622 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
   Biochemical - Metabolism (Intermediary) - effect on inflammation or
   mediation of inflammation
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,1006,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Gastrointestinal - other changes
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,1006,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 491 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
   Biochemical - Metabolism (Intermediary) - effect on inflammation or
   mediation of inflammation
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,1006,1977
 
                            *** END OF RECORD ***