*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UG1800000
CHEMICAL NAME           : Propionitrile, 2-ethoxy-
CAS REGISTRY NUMBER     : 14631-45-9
BEILSTEIN REFERENCE NO. : 1720500
REFERENCE               : 4-03-00-00675 (Beilstein Handbook Reference)
LAST UPDATED            : 199707
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C5-H9-N-O
MOLECULAR WEIGHT        : 99.15
WISWESSER LINE NOTATION : NC2O2
SYNONYMS/TRADE NAMES :
   * 2-Ethoxypropannitril
   * alpha-Ethoxypropionitrile
   * 2-Ethoxypropionitrile
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2860 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Nutritional and Gross Metabolic - other changes
REFERENCE :
   TNICS* Toxicology of New Industrial Chemical Substances.  English
   translation of TPKVAL.  (USSR Academy of Medical Sciences, Meditsina,
   Moscow, USSR)  Volume(issue)/page/year: 13,125,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2200 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Nutritional and Gross Metabolic - other changes
REFERENCE :
   TNICS* Toxicology of New Industrial Chemical Substances.  English
   translation of TPKVAL.  (USSR Academy of Medical Sciences, Meditsina,
   Moscow, USSR)  Volume(issue)/page/year: 13,125,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 2865 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 39(4),86,1974
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 940 mg/m3/17W-I
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Kidney, Ureter, Bladder - urine volume increased
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   TNICS* Toxicology of New Industrial Chemical Substances.  English
   translation of TPKVAL.  (USSR Academy of Medical Sciences, Meditsina,
   Moscow, USSR)  Volume(issue)/page/year: 13,125,1978

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-RUSSIA:STEL 50 mg/m3 JAN 1993

 
                            *** END OF RECORD ***